The rise of melatonin
Use of synthetic sleep hormone increased dramatically in both UK and US, especially among children
The regular use of melatonin to help children sleep has become "exceedingly common" in the US, a new study has found.
Nearly 1 in 5 (19%) children aged one to 14 were relying on the drug this year, according to research published in JAMA Pediatrics in November. That's up from an estimated 1.3% from 2017-18.
Although the controversial drug is recommended only as a short-term solution, children in the study were taking the supplement for 12-21 months – despite little research about the long-term effects, noted The Washington Post. While it is prescription-only in the UK, its general use here is also on the rise.
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"In an age of insomnia, melatonin has become a must-have sleep aid," said The Spectator magazine: "as ubiquitous as yoga or herbal tea."
What is melatonin?
Melatonin is a hormone naturally produced in the body that regulates sleep patterns. Levels rise at night before returning to normal during the day. Those struggling to sleep can take a synthetic version, which is classed as a drug in most countries and available only on prescription.
Unlike sleeping pills, which impact receptors in the brain to slow the nervous system, melatonin simply "signposts the brain towards sleep", Dr Sophie Bostock told The Spectator. However, "evidence it can help chronic sleeplessness is limited, and many experts are concerned by melatonin mania", said the magazine.
In the UK, it is mainly prescribed to those aged 55 and over struggling with insomnia and jet lag. It was approved for children in 2018 with much stricter guidance: licensed only for those with long-term sleep problems.
But in the US, melatonin is considered a supplement rather than a medication, so it is not as tightly regulated by the Food and Drug Administration (FDA). It is available over the counter, often in child-friendly sweets and gummies. A US health advisory warning urged parents this year to consult a doctor before giving it to children, but it is still the second most common supplement parents use after multivitamins, according to Harvard Health.
How much has use risen?
Between 2009 and 2018, use of melatonin in the US increased fivefold, said The Atlantic. About 27% of adults now take it, according to the US charity the National Sleep Foundation.
In England, use has also risen dramatically. From 2008-19, prescriptions increased from 2 in 1,000 people to nearly 20 in 1,000, according to a 2021 study published in British Journal of Clinical Pharmacology.
Prescriptions in the most deprived areas were generally 60% higher than in the least deprived areas. But the exact rate of usage is unknown, points out The Spectator. "Many more of us… buy it unlicenced online."
During the Covid-19 pandemic, sleep difficulties increased among all age groups thanks to more screen time, reduced exercise, disrupted routine and higher anxiety. But the pattern of increased use of melatonin was already stark. As The Atlantic noted, the pandemic "may have only accelerated this growing popularity".
What about among children?
Between 2015 and 2022, prescriptions to under-17s increased by 168%, according NHS data obtained by The Pharmaceutical Journal last year. In 2022, the number of under-17s being prescribed melatonin hit more than 60,000 – a figure experts described as "shocking".
The rate for children was almost five times higher than adults, and significantly higher than other European countries. Almost all had attention deficit hyperactivity disorder (ADHD) or were on the autism spectrum, the rise of which may correlate with the increase in melatonin prescriptions.
In the US, about 6% of children aged one to four, and 18% aged five to nine, were being given melatonin in 2023, according to the November study. The sample size for the study was small (1,000 parents) and not necessarily representative, the authors pointed out – but it was "telling nonetheless", said lead author Lauren Hartstein, of the Sleep and Development Lab at University of Colorado (CU) Boulder.
A survey in September also suggested that about 46% of American parents had given melatonin to children under the age of 13.
What are the risks?
Mild side effects include drowsiness, nausea and headaches, but overuse of melatonin has been linked to vomiting and joint pain.
Reports of melatonin ingestion to poison control centres in the US increased 530% from 2012 to 2021, according to the Centers for Disease Control and Prevention, largely among small children. By 2020, poison control centres were receiving more calls about paediatric overdoses on melatonin than on any other substance, noted The Atlantic.
The risk, said the CU Boulder study authors, is in the gummies: "They look and taste like candy."
An April study found that 22 out of 25 gummy products contained different amounts of melatonin than the label indicated. One had more than three times the amount, and some supplements were also found to contain serotonin.
As one doctor told The Spectator: "If you buy melatonin in Walmart you have absolutely no idea what dose it is."
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Harriet Marsden is a writer for The Week, mostly covering UK and global news and politics. Before joining the site, she was a freelance journalist for seven years, specialising in social affairs, gender equality and culture. She worked for The Guardian, The Times and The Independent, and regularly contributed articles to The Sunday Times, The Telegraph, The New Statesman, Tortoise Media and Metro, as well as appearing on BBC Radio London, Times Radio and “Woman’s Hour”. She has a master’s in international journalism from City University, London, and was awarded the "journalist-at-large" fellowship by the Local Trust charity in 2021.
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